Are, according to Download Squad:
- Acrobat Reader
- Real Player
- Internet Explorer
Some pretty easy targets there. I use only iTunes out of this list on a regular basis, which I have to because I have an iPod, as far as I am aware. Otherwise I occasionally use IE for sites which don’t like Firefox, but that’s more or less it.
Instead of Acrobat Reader, which I agree is a total nightmare, I use Foxit Reader; and for Real Player I use GOM Player. My email is handled by Google’s Gmail interface.